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It can also signify possession of the most typical or desirable masculine qualities: Male emphasizes the physical or sexual characteristics of a man; it may also refer to an animal or plant: In scientific and statistical use, male is the neutral contrastive term to female: Gentleman, once used only of men of high social rank, now also specifies a man of courtesy and consideration: Gentleman is also used as a polite term of reference This gentleman is waiting for a table or, only in the plural, of address Are we ready to begin, gentlemen?

See also manly , male. The man in the street wants peace, not war. Although some editors and writers reject or disregard these objections to man as a generic, many now choose instead to use such terms as human being s , human race, humankind, people, or, when called for by style or context, women and men or men and women.

See also -man , -person , -woman. Related Words for men father , brother , son , guy , fellow , husband , he , sir , beau , gentleman , grandfather , papa , swain , spouse , boyfriend , Mr.

Contemporary Examples of men Security officials told Agence France-Presse that the gas station manager said he had recognized the two men. Historical Examples of men Not only millionaires; but also painters and novelists and men and wo men of varied distinction.

The Spenders Harry Leon Wilson. Philothea Lydia Maria Child. The use of man to mean human beings in general is often considered sexist.

Gender-neutral alternatives include human beings , people and humankind. The verb to man can also often be replaced by to staff , to operate and related words.

Black slang a White man or White men collectively, esp when in authority, in the police, or held in contempt slang a drug peddler.

One of the most expressive G. At the kinges court, my brother, Ech man for himself. Published by Houghton Mifflin Company.

In addition to the idioms beginning with man man about town man in the street man of few words man of his word man of the moment man of the world many a many hands make light work many happy returns many is the also see: Nearby words for men memphian memphis memphite memphremagog memsahib men.

Jealous girlfriend drove partner's ex to suicide attempt by posting intimate pictures of her on Instagram. Withington 'Left to die' in a gentlemen's club, dancer who dreamed of new life in Australia Stacey Tierney's family say she was the victim of an 'injustice', but don't believe they will get answers.

Manchester Christmas Markets Manchester Christmas Markets prices - how much are sausages, beer and mulled wine this year?

The Christmas Markets are open now - we scoped out how much food and drink costs this year. Greater Manchester News Students taken ill after child brought 'pepper spray' into high school Fire crews, police and the ambulance service were called to Manchester Health Academy on Friday morning.

Christmas Markets Manchester Christmas Markets open - check out our first-look pictures. Manchester Christmas Markets Manchester's Ice Village - tickets, times and everything you need to know.

Football News Man City manager Pep Guardiola's hilarious reaction to claims his coaching is better than sex. Christmas Statues for festive Snowman trail are being brought to life - and you can watch the artists at work.

Manchester derby Will pubs near the Etihad be open after the Manchester derby? Policing plans revealed for City v United. Advertorial Smoking 5 smokers reveal the new method they're using to quit cigarettes for good mirror.

Manchester Christmas Markets Manchester Christmas Markets open today - here's everything you need to know It'll be the last time for at least four years that the main market hub will be based in Albert Square.

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Manchester Arena The Greatest Showman Live returns to Manchester - with live singers, dancers and circus performers Sing and dance along to the greatest show on earth at an immersive showing of The Greatest Showman.

Don't worry if you haven't got time to visit just yet as you have a whole six weeks to get involved in the festive fun before they finish.

The Trafford Centre Trafford Centre Christmas lights switch on - line up, times and everything you need to know. Christmas Markets Manchester Christmas markets parking: Car parks and nearby NCP multi-storeys The Christmas markets are back in Manchester - here are the best places to park your car in the city centre if you are driving.

Christmas Markets Take a look at our interactive map for the Christmas Markets There's no way you'll get lost around the stalls if you use this handy guide.

Stalybridge and Dukinfield Residents report hearing gun shots during 'disturbance' involving two vehicles Officers were called out to Ash Grove on Thursday night.

Manchester weather If you're going out this weekend make sure you take a brolly Heavy downpours are expected to lash Greater Manchester all weekend.

David Byrne at Manchester Arena. Emily Heward School for Scandal review: This new Manchester restaurant has some growing up to do. Calendar Girls at The Lowry.

Coronation Street's 'breathtaking and brutal' historic episode. Crime Police release CCTV image of man they want to speak to after newsagent attacked by robber Officers have released an image of a man they want to speak to following the robbery in Ashton-in-Makerfield.

Salford Council New piazzas and public space next to historic Stephenson's Bridge and beneath Ordsall Chord could open 'this winter'. Greater Manchester News Iceland's Christmas advert will not be shown on TV - because it's too political The supermarket decided to use their advert campaign to raise awareness against the use of palm oil in the production of food and cosmetics.

Northern This Northern Rail train leaks so much in the rain it has its own 'in-built shower'. Manchester Christmas Markets Manchester gives John Lewis a run for its money with another heartwarming Christmas advert for the city The sequel to last year's Santa animation is every bit as endearing.

Remembrance Lone pipers, church bells and burning beacons - Armistice Day in Manchester. Manchester Council The Regent Road roadworks have changed this morning - and frustrated drivers say it was gridlock.

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Men | All the action from the casino floor: news, views and more -

Sin City's bars takes in tiki dens, lounges housed in a chandelier and backstreet biker dives. But the spending bar is usually high for most of the "rewards," and since the games favor the house, odds are a gambler will lose money while racking up points. They rocked, rolled, and wrote songs. It's the 1 blog to bet on. If you refuse, they can have you arrested for loitering. They rocked, rolled, and wrote songs.

In these regions, men are now doing between 30 and 45 percent of the care work. Inside the guild, men in caps and long gowns sit in twos, weaving together in small rooms.

Not only millionaires; but also painters and novelists and men and wo men of varied distinction. She was in a box with two men —one old and one young—and an older woman.

We are like men in a subterranean cave, so chained that they can look only forward to the entrance.

Some of the people demanded what he had to say of the gods, since he had spoken so ably of men. Men who take from the poor daily interest for a drachma, and spend it in debauchery.

To separate the men from the boys in a figurative sense is from ; earliest uses tend to credit it to U. Plural men German Männer shows effects of i-mutation.

Liberman, for instance, writes, "Most probably man 'human being' is a secularized divine name" from Mannus [cf.

Sense of "adult male" is late c. Universal sense of the word remains in mankind and manslaughter.

Similarly, Latin had homo "human being" and vir "adult male human being," but they merged in Vulgar Latin, with homo extended to both senses.

A like evolution took place in Slavic languages, and in some of them the word has narrowed to mean "husband. Sanskrit nar- , Armenian ayr , Welsh ner , Greek aner.

Man also was in Old English as an indefinite pronoun, "one, people, they. As an interjection of surprise or emphasis, first recorded c.

Man-about-town is from ; the Man "the boss" is from To be man or mouse "be brave or be timid" is from s. Men's Liberation first attested Old English mannian "to furnish a fort, ship, etc.

Meaning "to take up a designated position on a ship" is first recorded s. Meaning "behave like a man, act with courage" is from c. Politics US midterm elections - what are they and what do they mean for Donald Trump?

The midterm elections are taking place across the United States of America today, but what exactly are they? Michelle Keegan Michelle Keegan takes her sausage dog for a walk and bumps into former City player Micah Richards The Our Girl actress and former Coronation Street star looked super-stylish while spotted out with her cute pet dachshund.

Offerton A gunman fired at a home in Stockport - police say it could have been a random attack. Barton Animal rescue centre bosses say dog suffered heart attack and died because of fireworks.

A fresh batch of celebrities will head out to the Australian jungle when the popular TV series returns on Sunday November Greggs Greggs are giving away free Festive Bakes in Manchester this week - here's how to get one The festive bake will be back in Greggs later this week as part of their Christmas menu and they will be available for free on Wednesday in Manchester city centre.

Etihad Stadium Muse confirm huge Manchester stadium gig for summer - how to get tickets. Traffic and travel Three young men killed in a horror smash in Buxton have been named.

Northern Quarter Callous vandal defaces huge Northern Quarter mural dedicated to 22 people killed at Manchester Arena.

Northern Northern extends new penalty fares - but operator promises you CAN still buy tickets on the train. Bury Can you help find this missing year-old man 'with a distinctive limp'?

Kalum Jones may be in urgent need of medical attention. Oldham Gang of 12 men smashed their way into Vodafone and Carphone Warehouse - before taking axe to police car.

Cristiano Ronaldo Manchester United fans hammer Cristiano Ronaldo after post-match comments Man Utd great Cristiano Ronaldo appeared to annoy some of the fans with his post-match comments following the win against Juventus.

Fashion PrettyLittleThing have won a lot of praise for this advert - featuring two different models The outfits are from the global brand's partywear collection in collaboration with American model Hailey Baldwin.

Oldham Cabbies waiting in the cold should 'get a coat' and turn their engines off, councillor says. Manchester Arena Mumford and Sons announce world tour and Manchester Arena show Mumford and Sons tickets and pre-sale information as the folk pop troupe head out on their biggest ever tour.

Manchester City Centre This batch of cocaine, cannabis and ecstasy was heading for Manchester city centre. Cheetham Hill Crooks smash down doors of 12 offices and steal cash from small business owners.

Prestwich Thief calmly walks into newsagent and steals Poppy Appeal collection box CCTV footage shows the man strolling out with the charity container just days before Armistice Day.

Stockport 'My daughter died after a battle with anorexia. Now I want to help other families going through the same horror' Pip McManus took her own life, aged just 15, after a three-year battle with anorexia.

Spice Girls Spice Girls tickets for Etihad Stadium reunion tour show in - how and when to get them. Christmas Markets The best Christmas markets to visit in the UK in Lucky for us here in Manchester, the city's festive attraction has been named the best in the UK.

But where else is good? Manchester City Centre Chips, gravy and generations of loyal customers - life in Manchester's busiest greasy spoon "If it's someone's birthday we'll cut a cake and get candles.

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Priestnall School Take a look inside the most expensive house sold in Greater Manchester in September - it's not in Hale Bury, Heywood and Stockport feature in September's millionaire's row.

Manchester City FC Man City Football Leaks revelations are missing a key piece of information Allegations about Manchester City's circumvention of the financial fair play rules have led to calls for punishment - but have they already BEEN punished for their transgressions?

Manchester The beautiful House of Cards-style video that will make you proud of Manchester. Traffic and travel Live Manchester traffic and travel updates on M62, M60, M6, trains and Metrolink Follow our live service bringing you constantly-updated reports on Greater Manchester's motorways, main roads, bus routes, train services and Metrolink lines.

Sixth celebrity is voted off after 'heartbreaking decision' The TV star lost to actor Charles Venn in the dance off. Catherine Tyldesley Coronation Street stars show support for charity founded by co-star Jennie McAlpine's father Corrie favourites attended an event to raise funds and awareness for the charity Moodswings founded by Jennie's father Tom.

Metrolink Members of the Armed Forces can travel on the Metrolink for free on Remembrance Sunday To also mark the centenary of the end of the First World War, Metrolink have placed poppy wreaths in the cabs of the Metrolink tram , the Lancashire Fusilier tram.

Rochdale Police issue urgent appeal for information after dad hit with baseball bat during carjacking Paul Schofield, 58, was left with a horrific laceration wound to his head following the terrifying attack in Rochdale.

Christmas The mum who's got Christmas all wrapped up - after finishing her shopping in September! It might be November, but mum Becki's festive planning is done and dusted.

Manchester weather Heavy rain and strong winds forecast for Greater Manchester over the weekend Anybody planning to attend a Remembrance Sunday event or the Manchester Derby is advised to take a raincoat or umbrella as it is going to be a wet one.

Manchester Family Christmas lights switch on events in Greater Manchester Hormone secretion is rarely altered as a result, and the significance of these abnormalities is uncertain.

Carcinoid tumors, particularly those derived from the embryologic foregut, occur in isolated cases. Multiple subcutaneous and visceral lipomas, angiofibromas, and collagenomas may also occur.

People with multiple endocrine neoplasia type 1 are born with one mutated copy of the MEN1 gene in each cell.

Then, during their lifetime, the other copy of the gene is mutated in a small number of cells. These genetic changes result in no functional copies of the MEN1 gene in selected cells, allowing the cells to divide with little control and form tumors.

This is known as Knudson's two-hit hypothesis [2] and is a common feature seen with inherited defects in tumor suppressor genes. Oncogenes can become neoplastic with only one activating mutation, but tumor suppressors inherited from both mother and father must be damaged before they lose their effectiveness.

The exception to the "two-hit hypothesis" occurs when suppressor genes exhibit dose-response, such as ATR. In a diagnostic workup individuals with a combination of endocrine neoplasias suggestive of the MEN1 syndrome are recommended to have a mutational analysis of the MEN1 gene if additional diagnostic criteria are sufficiently met, mainly including: Multiple endocrine neoplasia or MEN is part of a group of disorders that affect the body's network of hormone-producing glands the endocrine system.

Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body.

Multiple endocrine neoplasia involves tumors in at least two endocrine glands; tumors can also develop in other organs and tissues. These growths can be noncancerous benign or cancerous malignant.

If the tumors become cancerous, some cases can be life-threatening. The two major forms of multiple endocrine neoplasia are called type 1 and type 2.

These two types are often confused because of their similar names. However, type 1 and type 2 are distinguished by the genes involved, [1] the types of hormones made, and the characteristic signs and symptoms.

These disorders greatly increase the risk of developing multiple cancerous and noncancerous tumors in glands such as the parathyroid , pituitary , and pancreas.

Multiple endocrine neoplasia occurs when tumors are found in at least two of the three main endocrine glands parathyroid, pituitary, and pancreatico- duodenum.

Tumors can also develop in organs and tissues other than endocrine glands. The disorder affects 1 in 30, people. Although many different types of hormone-producing tumors are associated with multiple endocrine neoplasia, tumors of the parathyroid gland, pituitary gland, and pancreas are most frequent in multiple endocrine neoplasia type 1.

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